1560 - Iroquoian tribes south of the Great Lakes, at war with each other and surrounded by more numerous Algonquian enemies, are on the verge of extinction.The Iroquois Confederacy, the League of the Five Nations, is founded by Deganawidah and Hiawatha. 1600 - The name "Hurons" is given to the Wyandots of the Huron Confederacy by the French.At the invitation of Sieur Antoine de la Mothe Cadillac, Wyandots move south from Michilimackinac to settle in the vicinity of the new fort, but pro- and anti-French (anti-Catholic) divisions persist.Cadillac himself is hostile toward the Jesuits and their missionary efforts.1709-1742 - The Delaware gradually move in small groups from the Delaware River valley to lands controlled by the Iroquois on the West Branch of the Susquehanna in central Pennsylvania.
A few rejoin the main group of Delaware.1754 - Delaware in western Pennsylvania join the Shawnee in raiding the settlements, more out of hatred of the English than love of the French.
The town's French population still numbers just 65, with only 20 adult males. Hundreds of Hurons are put to death, along with Father Jean de Brebeuf and Father Gabriel Lalement.
March 16; 1,200 well-armed Iroquois launch coordinated attacks into Ouendake, wiping out the mission towns of St. Ossossane is abandoned as the Huron Confederacy disintegrates. In December, the Petun lose their principal town to the Iroquois.
Petun and Huron refugees leave Ontario, and spend the winter of 1649-50 on Mackinac Island.c.
1650 - First French contact with the Shawnee in Tennessee, where they have drifted from Ohio. The Five Nations temporarily control all the lands on either side of Lake Erie and Lake Ontario.1673 - In May, Father Marquette and Louis Joliet set out from St.